名字：侯德富

照片：

職稱：副教授

專(zhuān)業(yè)：醫(yī)學(xué)檢驗(yàn)技術(shù)、病理學(xué)與病理生理學(xué)

電子郵箱：defuhou@hunnu.edu.cn

通訊地址：bwin必贏生物化學(xué)與分子生物教研室，郵編：410013

簡(jiǎn)介：

侯德富，中南大學(xué)湘雅bwin必贏醫(yī)學(xué)博士，美國(guó)路易斯安那州立大學(xué)訪問(wèn)學(xué)者，bwin必贏副教授，碩士研究生導(dǎo)師。承擔(dān)各專(zhuān)業(yè)本科生《生物化學(xué)與分子生物學(xué)》理論和實(shí)驗(yàn)教學(xué)，留學(xué)生《biochemistry》全英文理論和實(shí)驗(yàn)教學(xué)。從事腫瘤發(fā)生的分子機(jī)制及腫瘤相關(guān)基因表達(dá)調(diào)控的分子機(jī)制、腫瘤藥物耐受機(jī)制及其治療等方面的研究工作。先后主持并完成教育部留學(xué)歸國(guó)基金、湖南省自然科學(xué)基金、湖南省教育廳自然科學(xué)研究項(xiàng)目、湖南師范大學(xué)博士啟動(dòng)基金、湖南師范大學(xué)青年基金、校級(jí)教改課題及精品課程等項(xiàng)目。

代表性學(xué)術(shù)論文：

1.Lyu H,Hou D, Liu H, Ruan S, Tan C, Wu J, Hicks C, Liu B. HER3 targeting augments the efficacy of panobinostat in claudin-low triple-negative breast cancer cells. NPJ Precis Oncol. 2023 Aug 3;7(1):72.

2.Zhong W, Shen Z, Wang M, Wang H, Sun Y, Tao X*,Hou D*. Tumor Microenvironment Responsive Nanomicelle with Folic Acid Modification Co-Delivery of Doxorubicin/Shikonin for Triple Negative Breast Cancer Treatment.Pharmaceuticals. 2023; 16(3):374.

3.Yi Zhang, Qing Jiang, Xinyi Liu, Liping Peng, Xinyi Tang, Ling Li, Xiao Ling, Xiaoping Yang, Chunlian He, Xiaojun Tao*,Defu Hou*. A Study of Hydrophobically Modified Pullulan Nanoparticles with Different Hydrophobic Densities on the Effect of Anti-Colon Cancer Cell Efficienc. J Biomed Nanotechnol . 2021 Oct 1; 17(10): 1972-1983.

4.Shuang Liu, Erik V Polsdofer, Lukun Zhou, Sanbao Ruan, Hui Lyu,Defu Hou,Hao Liu, Ann D Thor, Zhimin He, Bolin Liu.Upregulation of endogenous TRAIL-elicited apoptosis is essential for metformin-mediated antitumor activity against TNBC and NSCLC. Mol Ther Oncolytics . 2021 Apr 29; 21: 303-314.

5.侯德富,關(guān)瑞,萬(wàn)恂恂,陳主初.NFY結(jié)合位點(diǎn)缺失下調(diào)NPCEDRG基因啟動(dòng)子轉(zhuǎn)錄活性和效率.中國(guó)生物化學(xué)與分子生物學(xué)報(bào), 2013, 29(12): 1159-1165.

6.GUAN Rui,HOU De-Fu, RAO Xiang, GUAN Yong-Jun, OUYANG Yong-Mei, YU Yan-Hui, HU Jim, CHEN Zhu-Chu. ZNF403, a novel cell cycle regulator.生物化學(xué)與生物物理學(xué)進(jìn)展, 2013, 40(2): 147-158.

7.Guan R,Wen XY,Wu J,Duan R,Cao H,Lam S,Hou D,Wang Y,Hu J,Chen Z.Knockdown of ZNF403 inhibits cell proliferation and induces G2/M arrest by modulating cell-cycle mediators.Mol Cell Biochem.2012, 365(1-2):211-22.

8.Hou D, Guan Y, Liu J, Xiao Z, Ouyang Y, Yu Y, Chen Z.Cloning and characterization of the NPCEDRG gene promoter. Mol Cell Biochem. 2011, 346(1-2): 1-10.

9.侯德富,關(guān)勇軍,關(guān)瑞,歐陽(yáng)詠梅,余艷輝,陳主初.人NPCEDRG基因啟動(dòng)子的克隆及CCAAT/NFY結(jié)合位點(diǎn)初步分析。生物化學(xué)與生物物理學(xué)進(jìn)展，2011, 38(8): 713-723.

10.He Q, Zhang G,Hou D, Leng A, Xu M, Peng J, Liu T. Overexpression of sorcin results in multidrug resistance in gastric cancer cells with up-regulation of P-gp. Oncol Rep. 2011, 25(1): 237-43.

11.Hou DF, Wang SL, He ZM, Yang F, Chen ZC. Expression of CYP2E1 in human nasopharynx and its metabolic effectin vitro. Mol Cell Biochem.2007, 298(1-2): 93-100.