名字：何祖平
照片：
職稱：教授
職務(wù)：bwin必贏院長(zhǎng)
專業(yè)：病理學(xué)與病理生理學(xué)（碩士學(xué)位點(diǎn)），基礎(chǔ)醫(yī)學(xué)（博士學(xué)位點(diǎn)）
聯(lián)系電話：0731-88912446（Office）
電子郵箱：zupinghe@hunnu.edu.cn
通訊地址：湖南省長(zhǎng)沙市岳麓區(qū)桐梓坡路371號(hào)，bwin必贏辦公樓320室，郵編：410013
簡(jiǎn)介：
何祖平博士，bwin必贏院長(zhǎng)，湖南師范大學(xué)瀟湘學(xué)者特聘教授，博士生導(dǎo)師。上海高校特聘教授（東方學(xué)者）、湖湘高層次人才聚焦工程-杰出創(chuàng)新人才、上海市浦江人才計(jì)劃、上海市教委-上海交通大學(xué)bwin必贏雙百人計(jì)劃。國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目負(fù)責(zé)人，國(guó)家重大科學(xué)研究課題負(fù)責(zé)人，國(guó)家重點(diǎn)研發(fā)計(jì)劃課題負(fù)責(zé)人，國(guó)家自然科學(xué)基金面上項(xiàng)目負(fù)責(zé)人（3項(xiàng)），上海市科委重點(diǎn)項(xiàng)目負(fù)責(zé)人，湖南省重大專項(xiàng)課題負(fù)責(zé)人、湖南省重點(diǎn)研發(fā)計(jì)劃項(xiàng)目負(fù)責(zé)人。留美博士后和助理教授：2004年2月至2008年2月在美國(guó)喬治城大學(xué)從事博士后研究；2008年3月至2011年2月在美國(guó)喬治城大學(xué)擔(dān)任助理教授。2011年2月-2017年10為上海交通大學(xué)研究員，特聘教授，博士生導(dǎo)師。
他是國(guó)家杰出青年科學(xué)基金項(xiàng)目評(píng)審專家，國(guó)家高層次人才計(jì)劃評(píng)審專家。國(guó)家創(chuàng)新人才推進(jìn)計(jì)劃（創(chuàng)新人才、創(chuàng)新團(tuán)隊(duì)）評(píng)審專家。國(guó)家自然科學(xué)基金重大項(xiàng)目、重點(diǎn)項(xiàng)目、國(guó)際合作重點(diǎn)項(xiàng)目、面上項(xiàng)目、青年項(xiàng)目的通訊評(píng)審專家和/或會(huì)議評(píng)審專家。國(guó)家優(yōu)秀青年基金項(xiàng)目評(píng)審專家。湖南省“百人計(jì)劃”會(huì)評(píng)專家。上海市自然科學(xué)獎(jiǎng)主審專家（通訊評(píng)審、會(huì)議評(píng)審）。
長(zhǎng)期從事生殖醫(yī)學(xué)、細(xì)胞生物學(xué)、分子生物學(xué)研究。其研究成果已發(fā)表在國(guó)際著名期刊，如Nature子刊Cell Death and Differentiation（IF：10.7）。以通訊作者或第一作者已發(fā)表或接受發(fā)表SCI收錄論文73篇，合計(jì)SCI影響因子（IF）＞326。擔(dān)任SCI期刊Reproduction副主編。獲得湖南省自然科學(xué)獎(jiǎng)二等獎(jiǎng)、教育部科技進(jìn)步獎(jiǎng)二等獎(jiǎng)、上海醫(yī)學(xué)科技獎(jiǎng)一等獎(jiǎng)。
社會(huì)（學(xué)術(shù)）兼職：
1.模式動(dòng)物與干細(xì)胞生物學(xué)湖南省重點(diǎn)實(shí)驗(yàn)室主任
2.曾任上海市男科學(xué)研究所所長(zhǎng)
3.曾任上海市生殖醫(yī)學(xué)重點(diǎn)實(shí)驗(yàn)室副主任
4.再生醫(yī)學(xué)教育部重點(diǎn)實(shí)驗(yàn)室學(xué)術(shù)委員會(huì)委員
5.上海市生殖醫(yī)學(xué)重點(diǎn)實(shí)驗(yàn)室學(xué)術(shù)委員會(huì)委員
6.危重醫(yī)學(xué)代謝組學(xué)湖南省重點(diǎn)實(shí)驗(yàn)室學(xué)術(shù)委員會(huì)副主任
7.動(dòng)物腸道功能調(diào)控湖南省重點(diǎn)實(shí)驗(yàn)室學(xué)術(shù)委員會(huì)副主任
8.湖南省動(dòng)物腸道生態(tài)與健康國(guó)際創(chuàng)新合作基地學(xué)術(shù)委員會(huì)副主任
9.分子流行病學(xué)湖南省重點(diǎn)實(shí)驗(yàn)室學(xué)術(shù)委員會(huì)委員
10.中國(guó)生理學(xué)學(xué)會(huì)生殖科學(xué)專業(yè)委員會(huì)委員
11.中國(guó)動(dòng)物學(xué)會(huì)生殖生物學(xué)分會(huì)理事
12.國(guó)際生殖研究學(xué)會(huì)（SSR）成員委員會(huì)委員
13.湖南醫(yī)學(xué)會(huì)醫(yī)學(xué)教育委員會(huì)副主任委員
14.Reproduction副主編
15.Scientific Reports編委
16.Asian Journal of Andrology編委
獲得的人才項(xiàng)目（榮譽(yù)）：
1.上海高校特聘教授（東方學(xué)者），2012年，200萬元。
2.湖湘高層次人才聚集工程-杰出創(chuàng)新人才，2018年，100萬元。
3.上海市教委-上海交通大學(xué)bwin必贏高峰學(xué)科計(jì)劃（雙百人計(jì)劃），2015年，100萬元。
4.上海市浦江人才計(jì)劃，2011年。
主持的科研項(xiàng)目：
1.國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目，人精原干細(xì)胞自我更新與分化為精子細(xì)胞的分子機(jī)理研究，2013/01-2017/12，280萬元，項(xiàng)目負(fù)責(zé)人。
2.國(guó)家重點(diǎn)研發(fā)計(jì)劃，精子發(fā)生成熟障礙的表觀遺傳機(jī)制，2016/04-2021/06，557萬元，課題負(fù)責(zé)人。
3.國(guó)家重大科學(xué)研究計(jì)劃，減數(shù)分裂調(diào)控因子的篩查，2013/04-2014/08，248萬元，課題負(fù)責(zé)人。
4.國(guó)家重大科學(xué)研究計(jì)劃，精原干細(xì)胞命運(yùn)決定的表觀遺傳調(diào)控，2014/08-2018/08，95.8萬元，子課題負(fù)責(zé)人。
5.國(guó)家自然科學(xué)基金面上項(xiàng)目，PAK1調(diào)控人類精原干細(xì)胞自我更新與凋亡的作用及分子機(jī)制研究，2019/01-2022/12，60萬元，項(xiàng)目負(fù)責(zé)人。
6.國(guó)家自然科學(xué)基金面上項(xiàng)目，非編碼小RNA調(diào)控正常與異常人精原干細(xì)胞自我更新與分化的作用及其機(jī)制研究，2017/01-2020/12，60萬元，項(xiàng)目負(fù)責(zé)人。
7.國(guó)家自然科學(xué)基金面上項(xiàng)目，人精原干細(xì)胞誘導(dǎo)分化為成熟肝細(xì)胞及其信號(hào)轉(zhuǎn)導(dǎo)的研究，2012/01-2015/12，55萬元，項(xiàng)目負(fù)責(zé)人。
8.湖南省重大專項(xiàng)課題，生殖細(xì)胞異常導(dǎo)致出生缺陷的機(jī)制研究，2019/10-2022/10，190萬元，課題負(fù)責(zé)人。
9.湖南省重點(diǎn)研發(fā)計(jì)劃項(xiàng)目，重大生殖疾病人源化動(dòng)物模型的研究，2020/10-2022/09，50萬元，項(xiàng)目負(fù)責(zé)人。
10.上海市科委重點(diǎn)項(xiàng)目，microRNA對(duì)人類精原干細(xì)胞生成精子的調(diào)控作用及其機(jī)制，2013/01-2015/12，40萬元，項(xiàng)目負(fù)責(zé)人。
代表性學(xué)術(shù)論文（以通訊作者或第一作者已發(fā)表SCI收錄論文73篇，合計(jì)IF＞326，*為通訊作者，#為第一作者)：
1.Min Sun, Qingqing Yuan, MinghuiNiu, Hong Wang, Liping Wen, Chencheng Yao, Jingmei Hou, Zheng Chen, Hongyong Fu, Fan Zhou, Chong Li, Shaorong Gao, Wei-Qiang Gao, Zheng Li,Zuping He*. Efficient Generation of Functional Haploid Spermatids From Human Germline Stem Cells by Three-Dimensional Induced System.Cell Death and Differentiation,2018, 25: 747-764.IF: 10.7
2.Wei Chen,Yinghong Cui,Bang Liu,Chunyun Li,Li Du,Ruiling Tang,Lulu Qin,Yiqun Jiang,Jian Li,Xing Yu,Quanyuan He,Zuping He*.Hsa-miR-1908-3p Mediates the Self-Renewal and Apoptosis of Human Spermatogonial Stem Cells via Targeting KLF2,Molecular Therapy-Nucleic Acids, 2020, 20: 788-800.IF: 7.03
3.Hongyong Fu, Wenhui Zhang, Qingqing Yuan, MinghuiNiu, Fan Zhou, QianqianQiu, Guoping Mao, Hong Wang, Liping Wen, Min Sun, Zheng Li,Zuping He*.PAK1 Promotes the Proliferation and Inhibits Apoptosis of Human Spermatogonial Stem Cells via PDK1/KDR/ZNF367 and ERK1/2 and AKT Pathways.Molecular Therapy-Nucleic Acid, 2018, 12: 769-786.IF: 7.03
4.Hong Wang, Qingqing Yuan, MinghuiNiu, Wnihui Zhang, Liping Wen, Hongyong Fu, Fan Zhou,Zuping He*.Transcriptional regulation of P63 on the apoptosis of male germ cells and three stages of spermatogenesis in mice.Cell Death and Disease, 2018, 9(2):76.IF : 6.34
5.Hongyong Fu, Fan Zhou, Qingqing Yuan, Wenhui Zhang, QianqianQiu, Xing Yu,Zuping He*.MiRNA-31-5p Mediates the Proliferation and Apoptosis of Human Spermatogonial Stem Cells via Targeting JAZF1 and Cyclin A2.Molecular Therapy-Nucleic Acid,2018, 14: 90-100.IF : 7.03
6.Fan Zhou, Qingqing Yuan, Wenhui Zhang, MinghuiNiu, Hongyong Fu, QainqianQiu, Guiping Mao, Hong Wang, Liping Wen, Mujun Lu, Zheng Li,Zuping He*.MiR-663a Stimulates Proliferation and Suppresses Early Apoptosis of Human Spermatogonial Stem Cells by Targeting NFIX and Regulating Cell Cycle.Molecular Therapy-Nucleic Acid, 2018, 12: 319-336.IF : 7.03
7.Chencheng Yao, Qingqing Yuan, MinghuiNiu,Hongyong Fu, Fan Zhou, Wenhui Zhang,Hong Wang, Liping Wen, Ligang Wu,Zheng Li*,Zuping He*.Distinct expression profiles and novel targets of microRNAs in human spermatogonia, pachytene spermatocytes and round spermatids betweenOA patients and NOA patients.Molecular Therapy-Nucleic Acids, 2017, 9: 182-194.IF : 7.03
8.Bang Liu, Yinghong Cui, Wei Chen, Li Du, Chunyun Li,Cailin Wan,Zuping He*.Hsa-miR-100-3p Controls the Proliferation and DNA Synthesis and the Apoptosis of Human Sertoli Cells by Binding to SGK3.Frontiers in Cell and Developmental Biology. Published online on March 31, 2021. IF : 6.37
9.Fang Zhu,Yang Luo,Hao Bo,Guanghui Gong,Ruiling Tang,Jingyu Fan,Huan Zhang,Gang Liu,Wenbing Zhu,Yueqiu Tan,Zuping He*,Liqing Fan*.Trace the profile and function of circular RNAs in Sertoli cell only syndrome.Genomics,2021, 113:1845-1854. IF: 6.2
10.Rui Zhou, Jingrouzi Wu, Bang Liu,Yiqun Jiang, Wei Chen, Jian Li, Quanyuan He,Zuping He*.The roles and mechanisms of Leydig cells and myoid cells in regulating spermatogenesis.Cellular and Molecular Life Sciences, 2019,76, 2681-2696.IF: 7.01
11.Wei Chen, Yinghong Cu*, Minqi Ning, Haorui Zhang, Chenjun Yin,Zuping He*.The mechanisms and functions of microRNAs in mediating the fate determinations of human spermatogonial stem cells and Sertoli cells.Seminars in Cell and Developmental Biology,Accepted on May 4, 2021.IF: 6.69
12.Li Du, Wei Chen,Zixin Cheng, Si Wu1, Jian He, Lu Han, Wenbing Qin*, Zuping He*.Novel Gene Regulation in Normal and Abnormal Spermatogenesis.Cells,Published online on March 7, 2021.IF: 6.2
13.QianqianQiu, Xing Yu, Chencheng Yao,YujunHao, Liqing Fan, Chunyi Li, Peng Xu,Geng An, Zheng Li,Zuping He*.FOXP3pathogenic variants cause male infertility through affecting the proliferation and apoptosis of human spermatogonial stem cells.Aging, 2019,11(24):12581-12599. IF: 5.51
14.Hao Yang, Yang Liu, Yanan Hai, Yuehua Gong, Ying Guo, Shi Yang, Zhenzhen Zhang, Linhong Liu, Zheng Li, Wei-Qiang Gao,Zuping He*.Efficient conversion of mouse spermatogonial stem cells to phenotypic and functional dopaminergic neurons via PI3K/Akt and P21/Smurf2/Nolz1 pathway.Molecular Neurobiology,2015, 52(3):1654-1669.IF: 6.19
15.Shi Yang, Ping Ping, Meng Ma, Peng Li, Ruhui Tian, Hao Yang, Yang Liu, Yuehua Gong, Zhenzhen Zhang, Zheng Li*,Zuping He*. Generation of haploid spermatids with fertilization and development capacity from human spermatogonial stem cells of cryptorchid patients.Stem Cell Report, 2014, 3(4): 663-675.IF: 7.34
16.Yanan Hai, Yun Liu, Jingmei Hou, Zhen Chen,Zuping He*. The roles and regulation of Sertoli cells in spermatogenesis.Seminars in Cell and Developmental Biology, 2014, 29:66-75.IF: 6.69
17.Meng Ma, Shi Yang, Zhenzhen Zhang, Peng Li, Yuehua Gong, Linhong Liu, Yong Zhu, Ruhui Tian, Yufei Liu, Xiaobo Wang, Feng Liu, Lin He, Yang Liu, Hao Yang, Zheng Li*,Zuping He*.Sertoli cells from non-obstructive azoospermia and obstructive azoospermia patients show distinct morphology, raman spectrum and biochemical phenotype.Human Reproduction, 2013, 28(7):1863-1673.IF: 5.02
18.Chao Yang, ChenchengYao, Ruhui Tian, Zijue Zhu, LiangyuZhao, Peng Li, Huixing Chen, Yuhua Huang, ErleiZhi, Yuehua Gong, YunjingXue, Hong Wang, Qingqing Yuan,Zuping He*, Zheng Li*. miR-202-3p Regulates Sertoli Cell Proliferation, Synthesis Function, and Apoptosis by Targeting LRP6 and Cyclin D1 of Wnt/β-Catenin Signaling.Molecular Therapy-Nucleic Acids, 2018,14: 1-19.IF : 7.03
19.Ying Guo, Yanan Hai, Chencheng Yao, Zheng Chen, JingmeiHou, Zheng Li,Zuping He*. Long-term culture and significant expansion of human Sertoli cells whilst maintaining stable global phenotype and AKT and SMAD1/5 activation.Cell Communication and Signaling, 2015, 13: 20.
IF: 5.32
20.Zhenzhen Zhang, Yuehua Gong, Ying Guo, Yanan Hai, Hao Yang, Shi Yang, Yang Liu, Meng Ma, Linhong Liu, Zheng Li, Wei-Qiang Gao,Zuping He*. Direct transdifferentiation of spermatogonial stem cells to morphological, phenotypic and functional hepatocyte-like cells via the ERK1/2 and Smad2/3 signaling, pathways and the inactivation of cyclin A, cyclin B and cyclin E.Cell Signaling and Communications, 2013, 11:67. IF: 5.32
21.Zuping He#, Jiji Jiang, Maria Kokkinaki, Lin Tang, Wenxian Zeng, Ian Gallicano, Ina Dobrinski, Martin Dym. MiRNA-20 and MiRNA-106a Regulate Spermatogonial Stem Cell Renewal at the Post-Transcriptional Level via Targeting STAT3 and Ccnd1 2.Stem Cells, 2013, 31(10): 2205-2217.IF: 7.74
22.Zuping He#, Jiji Jiang, Maria Kokkinaki, Martin Dym. Nodal signaling via an autocrine pathway is required for proliferation of mouse spermatogonial stem/progenitor cells through smad2/3 and Oct-4 activation.Stem Cells,2009,27: 2580-2590. IF: 7.74
23.Zuping He#, Jiji Jiang, Maria Kokkinaki, NadyGolestaneh, Marie-Claude Hofmann, Martin Dym. Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation.Stem Cells,2008, 26:266-278.IF: 7.74
專利：
1.一種分離人精原干細(xì)胞的方法，專利號(hào)：ZL201110321182.9，何祖平，李錚，劉陽，劉建芳等。
2.一種人精原干細(xì)胞體外分化為功能精子細(xì)胞的三維誘導(dǎo)方法。專利號(hào)：ZL201610648584.2，何祖平，孫敏，袁青青，牛明輝，王洪，文麗平，付紅勇，周帆，李錚。
人才培養(yǎng)：
1.在上海交通大學(xué)培養(yǎng)博士研究生7名，畢業(yè)博士研究生7名；培養(yǎng)碩士研究生4名，畢業(yè)碩士研究生4名；指導(dǎo)博士后4名，出站博士后4名。博士研究生導(dǎo)師聘期考核結(jié)果優(yōu)秀。
2.在湖南師范大學(xué)培養(yǎng)博士研究生3名、碩士研究生4名；指導(dǎo)博士后2名、訪問學(xué)者1名。
