名字：鄒輝

照片：

職稱：副教授

職務(wù)：支部書記

專業(yè)：藥學(xué)，藥物化學(xué)

電子郵箱：zouhui@hunnu.edu.cn

通訊地址：湖南省長沙市岳麓區(qū)桐梓坡路371號，bwin必贏仁醫(yī)樓

郵編：410013

簡介：

博士，副教授，碩士生導(dǎo)師，bwin必贏藥學(xué)系支部書記，湖南師范大學(xué)世承人才，湖南師范大學(xué)優(yōu)秀青年人才計(jì)劃入選者。擔(dān)任小分子靶向藥物研究與創(chuàng)制湖南省重點(diǎn)實(shí)驗(yàn)室主任助理，天然藥物研究室主任。擔(dān)任《Journal of Food Chemistry》、《International Journal of Oncology》等雜志特邀審稿人。

主要研究方向基于化學(xué)生物學(xué)研究模式，以治療腫瘤、神經(jīng)退行性疾病等重大疾病的藥物發(fā)現(xiàn)為目標(biāo)，尋找和發(fā)現(xiàn)新穎活性天然產(chǎn)物，開展結(jié)構(gòu)修飾和生物學(xué)功能研究。先后從卷柏、翠云草、白術(shù)、蔓荊子等植物中分離鑒定化合物200余個(gè)，新化合物40余個(gè)。主持國家自然科學(xué)基金項(xiàng)目1項(xiàng)，湖南省自然科學(xué)基金項(xiàng)目1項(xiàng)，廳局級項(xiàng)目多項(xiàng)，參與國家自然科學(xué)基金、湖南省科技廳項(xiàng)目、湖南省中醫(yī)藥管理局重點(diǎn)項(xiàng)目等科研項(xiàng)目10余項(xiàng)；以第一作者或通訊作者身份發(fā)表科研論文20余篇，其中SCI論文12篇，論文發(fā)表在《Tetrahedron Letters》、《Hepatology International》、《Fitoterapia》、《Oncology Reports》等期刊。

社會（學(xué)術(shù)）兼職：

湖南省藥物會藥學(xué)教育委員會副秘書長；中國藥學(xué)會會員。

主持的科研項(xiàng)目：

國家自然科學(xué)基金青年項(xiàng)目，31400311，蔓荊子總黃酮靶向肝癌干細(xì)胞活性成分及作用機(jī)制研究，2014.01-2017.12，23萬元，項(xiàng)目負(fù)責(zé)人。

湖南省自然科學(xué)基金青年項(xiàng)目，2017JJ3213，藥用植物雞骨草抑制肝癌干細(xì)胞干性的活性成分及作用機(jī)制研究，2017.01-2019.12，5萬元，項(xiàng)目負(fù)責(zé)人。

湖南省教育廳課題，14C0709，中藥白術(shù)抗老年性癡呆先導(dǎo)化合物的發(fā)現(xiàn)，2014.09-2016.9，2萬元，項(xiàng)目負(fù)責(zé)人。

湖南師范大學(xué)青年優(yōu)秀人才培養(yǎng)計(jì)劃，ET15108，中藥雞骨草抗肝癌先導(dǎo)化合物的發(fā)現(xiàn)、結(jié)構(gòu)表征及構(gòu)效關(guān)系研究，2015.09-2018.06，10萬元，項(xiàng)目負(fù)責(zé)人。

企業(yè)橫向課題，藍(lán)金口服液臨床前研究，2019.06-2020.12，20萬元，項(xiàng)目負(fù)責(zé)人。

國家自然科學(xué)基金青年基金項(xiàng)目，81703199，p62依賴的選擇性自噬對實(shí)驗(yàn)性矽肺纖維化的作用及機(jī)制研究，2018.01-2020.12，20萬元，在研，項(xiàng)目主要參與人。

代表性學(xué)術(shù)論文：

1. Fuxuan Wu#, Miaomiao Yu#, Wanling Chen, Lu Zhou, Dan Zhang, Yujie Peng, Xifeng Sheng, Hui Zou*, Junjiang Fu*. A New Isoflavonolignan Glycoside from Abrus cantoniensis, Records of Natural Products, 2019,13:(5):418-423.

2. Miaomiao Yu, Fuxuan Wu, Wanling Chen, Junwei Kuang, Lu Zhou, Junjiang Fu, Xifeng Sheng*, Hui Zou*. A new isoflavone glycoside from Abrus cantoniensis, 2019, online. Doi:10.1080/10286020.2019.1598394.

3. Ting Tao, Caimei He, Jun Deng, Yanjun Huang, Qiongli Su, Mei Peng, Meiling Yi, Kwame Oteng Darko, Hui Zou*, Xiaoping Yang*. A novel synthetic derivative of quercetin, 8-trifluoromethyl- 3,5,7,3',4'-O-pentamethyl-quercetin, inhibits bladder cancer growth by targeting the AMPK/mTOR signaling pathway. Oncotarget, 2017, 8(42): 71657.

4. Hui Zou, Pingsheng Xu, Rui Liu, Zhenxing Zou, Jing Li, Aiguo Zhong, Jianzhong Hu, Kangping Xu*, Guishan Tan*. Selacyclicbiflavone A, an unusual macrocyclic biflavone from Selaginella uncinata (Desv.) Spring. Tetrahedron Letters, 2016, 57(8): 892-894.

5. Hui Zou, Xiaozheng Cao, Qiao Xiao, Xifeng Sheng, Kaiqun Ren, Meifang Quan, Zhenwei Song, Duo Li, Yu Zheng, Wenbing Zeng, Jianguo Cao, Yaojin Peng*. Synergistic inhibition of characteristics of liver cancer stem-like cells with a combination of sorafenib and 8-bromo-7-methoxychrysin in SMMC-7721 cell line. Oncology Reports, 2016, 36(3): 1731-1738.

6. Xiaozheng Cao, Kaiqun Ren, Zhenwei Song, Duo Li, Meifang Quan, Yu Zheng, Jianguo Cao, Wenbing Zeng, Hui Zou*. 7-Difluoromethoxyl-5,4'-di-n-octyl genistein inhibits the stem-like characteristics of gastric cancer stem-like cells and reverses the phenotype of epithelial-mesenchymal transition in gastric cancer cells. Oncology Reports, 2016, 36(2): 1157-1165.

7. Xiaocheng Cao#, Hui Zou#, Jianguo Cao, Yinghong Cui, Suwen Sun, Kaiqun Ren, Zhenwei Song, Duo Li, Meifang Quan*. A candidate Chinese medicine preparation-Fructus Viticis Total Flavonoids inhibits stem-like characteristics of lung cancer stem-like cells. BMC Complementary and Alternative Medicine. 2016, 16: 364.

8. Hui Zou*, Xing Feng, Jianguo Cao. Twist in hepatocellular carcinoma: pathophysiology and therapeutics. Hepatology International, 2015, 9(3): 399-405.

9. Hui Zou, Meiling Yi, Kangping Xu, Xifeng Sheng, Guishan Tan*. Two new flavonoids from Selaginella uncinata. Journal of Asian Natural Products Research, 2015, 18(3): 248-252.

10. Hui Zou, Kangping Xu, Fushuang Li, Zhenxing Zou, Rui Liu, Ruihuan Liu, Jing Li, Leihong Tan, Guishan Tan*. Unciflavones A-F, six novel flavonoids from Selaginella uncinata (Desv.) Spring. Fitoterapia, 2014; 99: 328-333.

11. Hui Zou, Kangping Xu, Zhenxing Zou, Hongping Long, Hui Wang, Fushuang Li, Jing Li, Junwei Kuang, Guang Li, Guishan Tan. A new flavonoid with 6-phenyl substituent from Selaginella uncinata. Journal of Asian Natural Products Research, 2013, 15(1): 84-88.

12. Hui Zou, Kangping Xu, Fushuang Li, Zhenxing Zou, Hongping Long, Guang Li, Hui Wang, Guishan Tan*. Uncinataflavone, a new flavonoid with a methyl benzoate substituent from Selaginella uncinata. Journal of Asian Natural Products Research, 2013, 15(4): 408-412.