姓名：文朗
照片：
電子郵箱：wenlang@hunnu.edu.cn
通訊地址：湖南省長沙市岳麓區(qū)桐梓坡路371號(hào)，bwin必贏生物化學(xué)與分子生物學(xué)教研室，郵編：410013
簡介:文朗，博士，本科就讀于華中科技大學(xué)生物醫(yī)學(xué)工程專業(yè)，獲工學(xué)學(xué)士學(xué)位，后保送至中國科學(xué)技術(shù)大學(xué)生命科學(xué)學(xué)院碩博連讀，獲神經(jīng)生物學(xué)博士學(xué)位，主要運(yùn)用小鼠行為學(xué)、膜片鉗電生理等技術(shù)，研究免疫分子等參與腦認(rèn)知功能、調(diào)控突觸傳遞的機(jī)制。相關(guān)成果發(fā)表于Trends in Neurosciences、Cell Reports等期刊。
代表性學(xué)術(shù)論文：
(1)Lang Wen, Danlei Bi, Yong Shen. Complement-mediated synapse loss in Alzheimer’s Disease: Mechanisms and Involvement of Risk Factors.Trends in Neurosciences. 2024, 47, 53-69
(2)Lang Wen, Zujun Wu, Xiaoli Yang, Shumei Fu, Yaxi Zhan, Zuolong Chen, Danlei Bi, Yong Shen. The Complement Inhibitor CD59 is Required for GABAergic Synaptic Transmission in the Dentate Gyrus.Cell Reports. 2023, 42, 112349-112368
(3) Xiaoqun Wang, Xiaoli Yang, Zhuanghao Hou, Shuangshuang Tian, Guangwei Xu, Jianyu Li,Lang Wen, Danlei Bi, Feng Gao, Yong Shen, Guangming Huang. Whole-brain mapping of metabolic alterations in a mouse model of Alzheimer's disease by desorption electrospray ionization mass spectrometry imaging.Talanta, 2023, 253, 124046.
(4) Danlei Bi,Lang Wen, Zujun Wu, Yong Shen. GABAergic dysfunction in excitatory and inhibitory (E/I) imbalance drives the pathogenesis of Alzheimer’s disease.Alzheimers Dement. 2020, 16, 1312-1329.
(5)Lang Wen, Danlei Bi, Yong Shen. A New Mechanism of Alzheimer’s Disease: Hyperactivity of Neurons Due To GABAa Receptor Dysfunction.Alzheimers Dement. 2019, 15(7S), 642. AAIC 2019 (Poster)
(6)畢丹蕾,文朗,熊偉,申勇.阿爾茨海默病的可能藥物靶點(diǎn)和臨床治療研究進(jìn)展.中國藥理學(xué)與毒理學(xué)雜志, 2015, 29, 507-536
(7) Jie Yang, Ming-Hao Yao,Lang Wen, Ji-Tao Song, Ming-Zhen Zhang, Yuan-Di Zhao, Bo Liu, Multifunctional quantum dot–polypeptide hybrid nanogel for targeted imaging and drug delivery.Nanoscale, 2014, 6, 11282-11292.
