姓名：張玉靜

照片：

 職稱：副教授 

 簡介：

張玉靜，博士，校聘副教授，碩士生導師，重點實驗室副主任，主要從事環(huán)境化學物誘導肝毒性損傷的分子毒理學研究。擔任湖南省預防醫(yī)學會營養(yǎng)學委員會理事。

教育經(jīng)歷：

2014.09-2017.06中南大學公共衛(wèi)生學院 公共衛(wèi)生與預防醫(yī)學

2011.09-2014.06中山大學公共衛(wèi)生學院 衛(wèi)生毒理學

2006.09-2011.06青島大學公共衛(wèi)生學院 預防醫(yī)學

科研文章：

1.Yujing Zhang, Gang Yang, Shuai Huang, Xinyue Yang, Fengyan Yuan, Sulai Liu, Xing Yu, Reg ulation of Cr(VI)-induced Premature Senescence in L02 Hepatocytes by ROS-Ca2+- NF-κB Signaling, Oxidative medicine and cellular longevity, 2022, 2022.

2.Yujing Zhang, Shuai Huang, Gang Yang, Lianhogn Zou, Xin Huang, Sulai Liu, The Role of miRNAs during Endoplasmic Reticulum Stress Induced Apoptosis in Digestive Cancer, Journal of Cancer, 2021,12(22):6787-6795.

3.Yujing Zhang,Shuai Huang, Shiyi Tan, Mingke Chen, Shang Yang, Shi Chen, 3-methyadenine inhibits lipopolysaccharides-induced pulmonary inflammation at the early stage of silicosis via blocking NF-κB signaling pathway, Toxicology and Industrial Health, 2021.

4.Yujing Zhang,Yu Ma, Yuanyuan Xiao, Chan Lu, Fang Xiao, Drp1-dependent mitochondrial fission contributes to Cr(VI)-induced mitophagy and hepatotoxicity, Ecotoxicology and Environmental Safety, 2020, 203:110928.

5.Yujing Zhang,Huanfeng Bian, Yu Ma, Yuanyuan Xiao, Fang Xiao, Cr(VI)-induced overactive mitophagy contributes to mitochondrial loss and cytotoxicity in L02 hepatocytes. Biochemical Journal, 2020, 477(14):2607-2619.

6. Yu Ma#,Yujing Zhang#, Yuanyuan Xiao, Fang Xiao, Increased Mitochondrial Fragmentation Mediated by Dynamin-Related Protein 1 Contributes to Hexavalent Chromium-Induced Mitochondrial Respiratory Chain Complex I-Dependent Cytotoxicity, Toxics. 2020, 8(3):E50.

7.Yujing Zhang, Yu Ma, Ningjuan Liang, Yuehui Liang, Chan Lu, Fang Xiao, ROS-mediated miR-21-5p regulates the proliferation and apoptosis of Cr(VI)-exposed L02 hepatocytes via targeting PDCD4, Ecotoxicology and Environmental Safety, 2020,191:110160.

8.Yujing Zhang, Yu Ma, Ningjuan Liang, Yuehui Liang, Chan Lu, Fang Xiao, Blockage of ROS-ERK-DLP1 signaling and mitochondrial fission alleviates Cr(VI)-induced mitochondrial dysfunction in L02 hepatocytes. Ecotoxicology and Environmental Safety, 2019, 186:109749.

9.Yujing Zhang,Yiyuan Zhang, Yuanyuan Xiao, Caigao Zhong, Fang Xiao, High expression of Clusterin suppresses Cr(VI)-induced premature senescence through activation of PI3K/AKT pathway, Ecotoxicology and Environmental Safety, 2019 ,183:109465.

10.Yujing Zhang, Fang Xiao, Xinmin Liu, Kaihua Liu, Xiaoxin Zhou, Caigao Zhong, Cr(VI) induces cytotoxicity in vitro through activation of ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction via the PI3K/Akt signaling pathway, Toxicology in Vitro, 2017, 41: 232-234.

11.Yujing Zhang, Yiyuan Zhang, Caigao Zhong, Fang Xiao, Cr(VI) induces premature senescence through ROS-mediated p53 pathway in L-02 hepatocytes, Scientific Reports, 2016, 6: 34578.

12. Xin Huang, Zuodong Li, Jun Lei, Dapeng Wang,Yujing Zhang(通訊作者), Genetic polymorphism in DGCR8 is associated with late onset of preeclampsia, BMC Pregnancy and Childbirth, 2019, 20(1):151.

13.Fengyan Yuan, Yiyuan Yang, Huiqin Zhou, Jing Quan, Chongyang Liu, Yi Wang,Yujing Zhang(通訊作者), Xing Yu, Heparanase in cancer progression: Structure, substrate recognition and therapeutic potential, Frontiers in Chemistry, 2022,10:926353.

14. Xing Yu, Jing Quan, Shuai Chen, Xinyue Yang, Shuai Huang, Gang Yang,Yujing Zhang^#.A protocol for Rapid Construction of Senescent CellsFront Integr Neurosci, 2022,16:929788.

15.張玉靜,蔣妮,柳強,朱勇飛,黃昕.線粒體損傷在鎘誘導肝細胞凋亡和DNA損傷中的作用[J].衛(wèi)生研 究,2020,49(02):290-297.

16.張玉靜,鐘才高,環(huán)境內(nèi)分泌干擾物的肝毒性作用研究進展.中國藥理學與毒理學雜 志,32(6):484-489.

17.張玉靜,鐘才高,鈣離子依賴的內(nèi)質(zhì)網(wǎng)應(yīng)激在細胞凋亡中作用研究進展,中國職業(yè)醫(yī)學, 2017, 44(03): 365-370.

18.張玉靜,陳慧峰,廖昆,夏斌,殷花,何承勇,林育純,林忠寧,鎘對肝細胞中PPP2R1A啟動子 區(qū)甲基化及其轉(zhuǎn)錄水平的影響,中國職業(yè)醫(yī)學, 2014, 41(05): 496-501.

科研項目：

1.國家自然科學基金青年基金項目，81803272，miR-21在Cr(Ⅵ)誘導內(nèi)質(zhì)網(wǎng)應(yīng)激反應(yīng)性肝細胞凋亡中的作用及其機制研究，2019/01-2021/12，21萬元，主持。

2.湖南省自然科學基金青年基金項目，2020JJ5385，PERK在長期低劑量Cr(Ⅵ)暴露誘導肝細胞早 熟性衰老中的作用及機制研究，2020/01-2022/12，5萬元，主持。

3.湖南省衛(wèi)健委,一般項目, 202212045173, RCN1/PERK信號通路在Cr(Ⅵ)致肝細胞早衰中的作用及機制研究, 2022-01至2024-12, 4萬元,主持。

4.湖南省教育廳一般項目，19C1155，基于PERK/ Nrf2信號通路探討Cr(Ⅵ)誘導肝細胞早衰的內(nèi) 質(zhì)網(wǎng)應(yīng)激機制，2019/10-2022/09，2萬元，主持。

5.湖南師范大學科學研究啟動基金，[Cr(VI)]誘導肝細胞早衰的價值研究，2018/05-2020/05，3萬元，主持。

專利：

ZL202110265256.5一種血吸蟲蟲卵檢測濾膜的制作裝置。(排名第二)

指導學生：

1.湖南省大學生創(chuàng)新性訓練項目，2項

2.全國大學生生命科學競賽，國家三等獎、湖南賽區(qū)二等獎

3.湖南師范大學優(yōu)秀本科畢業(yè)論文，1項

聯(lián)系方式：18163683079

zhangyujing@hunnu.edu.cn；zhangyujing24@163.com