名字：張慧慧

照片：

職稱(chēng)：講師

專(zhuān)業(yè)：病原生物學(xué)

電子郵箱：huitomorrow@163.com

通訊地址：至謹(jǐn)樓331

簡(jiǎn)介：

2015.7-今 bwin必贏 講師

2014.8-2015.6湖南省醫(yī)學(xué)表觀基因組學(xué)重點(diǎn)實(shí)驗(yàn)室 博士后

2009.9-2014.6武漢大學(xué)生命科學(xué)學(xué)院 博士

2005.9-2009.6山東師范大學(xué)生命科學(xué)學(xué)院 學(xué)士

主持課題項(xiàng)目：

1.項(xiàng)目負(fù)責(zé)人：國(guó)家自然科學(xué)基金面上青年項(xiàng)目（81602450），2017.01-2019.12

4.項(xiàng)目負(fù)責(zé)人：湖南省自然科學(xué)基金青年基金項(xiàng)目（2018JJ3337），2018.01-2020.12

5.項(xiàng)目負(fù)責(zé)人：湖南省教育廳基金優(yōu)秀青年項(xiàng)目（16B161），2016.01-2018.12

6.項(xiàng)目負(fù)責(zé)人：湖南省衛(wèi)生計(jì)生委科研項(xiàng)目C類(lèi)（C2016045），2016.01-2017.12

代表性學(xué)術(shù)論文：

1. Zhang, H.H., Li, S.Z., Zhang, Z.Y., Hu, X.M., Hou, P.N., Gao, L., Du, R.L., and Zhang, X.D. (2014). Nemo-like kinase is critical for p53 stabilization and function in response to DNA damage. Cell death and differentiation21, 1656-1663.

2. Zhang, M.H., Zhang, H.H., Du, X.H., Gao, J., Li, C., Shi, H.R., and Li, S.Z. (2019). UCHL3 promotes ovarian cancer progression by stabilizing TRAF2 to activate the NF-kappaB pathway. Oncogene.

3. Li, S.Z., Shu, Q.P., Song, Y., Zhang, H.H., Liu, Y., Jin, B.X., Liuyu, T.Z., Li, C., Huang, X.C., Du, R.L., et al.(2019). Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response. Nature communications10, 3233.

4. Zhao, H., Pan, W.M., Zhang, H.H., Song, Y., Chen, J., Xiang, Y., Gu, B., Li, S.Z., Du, R.L., and Zhang, X.D. (2019). Cancer testis antigen 55 deficiency attenuates colitis-associated colorectal cancer by inhibiting NF-kappaB signaling. Cell death & disease10, 304.

5. Su, T., Zhu, J., Sun, R., Zhang, H., Huang, Q., Zhang, X., Du, R., Qiu, L., and Cao, R. (2019). Design, synthesis and biological evaluation of new quinoline derivatives as potential antitumor agents. European journal of medicinal chemistry178, 154-167.

6. Li, S.Z., Zeng, F., Li, J., Shu, Q.P., Zhang, H.H., Xu, J., Ren, J.W., Zhang, X.D., Song, X.M., and Du, R.L. (2018). Nemo-like kinase (NLK) primes colorectal cancer progression by releasing the E2F1 complex from HDAC1. Cancer letters431, 43-53.